COX-2-IN-59

COX-2-IN-59 is a potent and selective COX-2 inhibitor with an IC50 of 0.052 μM. COX-2-IN-59 exhibits 200-fold selectivity over COX-1 (IC50 = 11.16 μM) . COX-2-IN-59 reduces COX-2 levels, induces cell cycle arrest, and triggers apoptosis by increasing Bax expression, decreasing Bcl-2 levels, and activating caspase-3. COX-2-IN-59 can be used for the research of colon cancer[1].

Product Specifications

UNSPSC

12352005

Target

Apoptosis; Bcl-2 Family; Caspase; COX

Related Pathways

Apoptosis; Immunology/Inflammation

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

CC(NC1=CC=C(OCC(N/N=C/C2=CC=C(OS(=O)(C)=O)C=C2)=O)C=C1)=O

Molecular Formula

C18H19N3O6S

Molecular Weight

405.42

References & Citations

[1]Kassem AF, et al. Dual Anticancer and COX-2 Inhibitory Activity of Tailored Paracetamol-Alkanesulfonate Conjugates: A Promising Therapeutic Approach. Arch Pharm (Weinheim) . 2025;358 (10) :e70125.