Antimalarial agent 53

Antimalarial agent 53 is an antimalarial agent. Antimalarial agent 53 blocks protein synthesis by inhibiting the cytoplasmic ribosomes of malaria parasites, exhibiting potent antimalarial activity (IC50 = 3.9 nM) and good selectivity. Antimalarial agent 53 has no cross resistance and good safety. Antimalarial agent 53 can be used for research on malaria[1].

Product Specifications

UNSPSC

12352005

Target

Parasite

Related Pathways

Anti-infection

Field of Research

Infection

Smiles

O=C(NC1=CC(NN2CCN(C)CC2)=CC=C1O)C3=CC(OC4=CC(C(F)(F)F)=CC=N4)=CC=C3

Molecular Formula

C24H24F3N5O3

Molecular Weight

487.47

References & Citations

[1]Bravo P, et al. A Novel Antimalarial Agent that Inhibits Protein Synthesis in Plasmodium falciparum. Angew Chem Int Ed Engl. 2025 Oct 20:e202514085.