BL-1005
BL-1005 (BS2463), thiophen-2-yl pyrimidine (TTP), is a potent paralytic of Schistosoma mansoni with an EC50 of 37 nM. BL-1005 shows low cytotoxicity for HEK293, HeLa and HepG2 cell with CC50 >20 μM. BL-1005 can induce paralysis in both adult and juvenile S. mansoni. BL-1005 can be used for the research of infection[1].
Product Specifications
Product Name Alternative
BS2463
UNSPSC
12352005
Target
Parasite
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Smiles
FC(C=C(C=C1F)N)=C1C(C(Cl)=NC(C2=CC=CS2)=N3)=C3NCC4(C)COC4
Molecular Formula
C19H17ClF2N4OS
Molecular Weight
422.88
References & Citations
[1]Francisco KR, et al. Structure-Activity Relationship and Target Investigation of Thiophen-2-yl-Pyrimidines against Schistosoma species. bioRxiv [Preprint]. 2025 Oct 8:2025.10.07.681061.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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