PROTAC IKKβ/NR4A1 degrader-1
PROTAC IKKβ/NR4A1 degrader-1 is a highly efficient and effective dual-PROTAC degrader targeting IKKβ and NR4A1. PROTAC IKKβ/NR4A1 degrader-1 can increase the levels of caspase 3 and cleaved caspase 3 proteins, while the necroptosis marker RIP kinase remained unchanged, indicating that it can induce apoptosis. PROTAC IKKβ/NR4A1 degrader-1 can be used for the study of Acute myeloid leukemia (AML) . Red: IKKβ/NR4A1 ligand (HY-13067) ; Blue: E3 ligase CRBN ligand (HY-14658) ; Black: Linker (HY-79577) [1].
Product Specifications
CAS Number
[2826215-20-5]
UNSPSC
12352005
Target
Caspase; IKK; Necroptosis; Nuclear Hormone Receptor 4A/NR4A; PROTACs
Related Pathways
Apoptosis; NF-κB; PROTAC; Vitamin D Related/Nuclear Receptor
Field of Research
Cancer; Inflammation/Immunology
Smiles
[H][C@@]12C[C@](C(NCCCCCCNC3=CC=CC4=C3C(N(C4=O)C5CCC(NC5=O)=O)=O)=O)(CC[C@@]1(CC[C@@]6(C7=CC=C8C([C@@]7(CC[C@]62C)C)=CC(C(O)=C8C)=O)C)C)C
Molecular Formula
C48H60N4O7
Molecular Weight
805.01
References & Citations
[1]Maharjan CK, et al. Dual Targeting of IKKβ and NR4A1 for AML Therapy. bioRxiv [Preprint]. 2025 Sep 27:2025.09.24.678355.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Caspase 3; IKK-β; Nur77/NR4A1
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