HPK1-IN-64
HPK1-IN-64 is a potent, selective, and orally active HPK1 inhibitor with an IC50 value of 1.9 nM. HPK1-IN-64 exhibits selectivity exceeding 100-fold, 80-fold, 300-fold, and 350-fold against off-target kinases such as GLK, MAP4K5, TBK1, and TNIK, respectively. HPK1-IN-64 inhibits SLP76 protein phosphorylation and IL-2 secretion. HPK1-IN-64 may be used in cancer research, such as for colorectal cancer[1].
Product Specifications
CAS Number
3034320-17-4
UNSPSC
12352005
Target
Interleukin Related; MAP4K
Related Pathways
Immunology/Inflammation; MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
O=C1C(C2=C(C=C3C4=CN=C5N4CCC[C@H]5OC)C(C)(C6=CC(N7CCOCC7)=CC=C6N2)C)=C3CN1
Molecular Formula
C29H33N5O3
Molecular Weight
499.60
References & Citations
[1]Xi B, et al. Pocket-based molecule generation with an SE (3) -equivariant language model leads to a potent and selective HPK1 inhibitor with in vivo efficacy[J]. bioRxiv, 2025: 2025.09. 23.678079.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
IL-2; MAP4K1/HPK1
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