ISR activator 1
ISR activator 1 is an eIF2B allosteric inhibitor. ISR activator 1 stabilizes the inactive state of eIF2B, inhibits translation initiation and global protein synthesis, and selectively activates the ISR pathway. ISR activator 1 can be used for research on cancer and viral infections[1].
Product Specifications
UNSPSC
12352005
Target
Eukaryotic Initiation Factor (eIF)
Related Pathways
Cell Cycle/DNA Damage
Field of Research
Cancer; Infection
Smiles
CC(N(CC1=CC=CC(C2=CC3=C(C(C(F)(F)F)=C2)CCC[C@H]3N(C(CCOCCOCCC(N([C@@H]4CCCC5=C4C=C(C=C5C(F)(F)F)C6=CC=CC(CN(C(C)=O)C)=C6)C)=O)=O)C)=C1)C)=O
Molecular Formula
C52H60F6N4O6
Molecular Weight
951.05
References & Citations
[1]Shilliday F, et al. A molecular stabiliser of an inhibitory eIF2B-eIF2 (αP) complex activates the Integrated Stress Response[J]. bioRxiv, 2025: 2025.09. 25.678332.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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