ISR activator 1

ISR activator 1 is an eIF2B allosteric inhibitor. ISR activator 1 stabilizes the inactive state of eIF2B, inhibits translation initiation and global protein synthesis, and selectively activates the ISR pathway. ISR activator 1 can be used for research on cancer and viral infections[1].

Product Specifications

UNSPSC

12352005

Target

Eukaryotic Initiation Factor (eIF)

Related Pathways

Cell Cycle/DNA Damage

Field of Research

Cancer; Infection

Smiles

CC(N(CC1=CC=CC(C2=CC3=C(C(C(F)(F)F)=C2)CCC[C@H]3N(C(CCOCCOCCC(N([C@@H]4CCCC5=C4C=C(C=C5C(F)(F)F)C6=CC=CC(CN(C(C)=O)C)=C6)C)=O)=O)C)=C1)C)=O

Molecular Formula

C52H60F6N4O6

Molecular Weight

951.05

References & Citations

[1]Shilliday F, et al. A molecular stabiliser of an inhibitory eIF2B-eIF2 (αP) complex activates the Integrated Stress Response[J]. bioRxiv, 2025: 2025.09. 25.678332.