Axl-IN-20

Axl-IN-20 (Compound w11) is a selective, orally active AXL inhibitor, with an IC50 of 5 nM. Axl-IN-20 has antitumor activity against hematological malignancies[1].

Product Specifications

CAS Number

[2487649-59-0]

UNSPSC

12352005

Target

TAM Receptor

Related Pathways

Protein Tyrosine Kinase/RTK

Field of Research

Cancer

Smiles

CN1C=C(C2=C1N=CN=C2N)C3=CC=C(C=C3)NC(C4=C5CCCN5N(C4=O)C6=CC=CC=C6)=O

Molecular Formula

C26H23N7O2

Molecular Weight

465.51

References & Citations

[1]Sun M, et al. Structure-based drug discovery of novel penta- or hexa-bicyclo-pyrazolone derivatives as potent and selective AXL inhibitors. RSC Med Chem. 2025 Aug 9.