PLK4-IN-5

PLK4-IN-5 is a PLK4 (IC50 = 0.8 nM) inhibitor. PLK4-IN-5 can inhibit MCF-7 cell clone formation, induce cell cycle arrest (S/G2 phase), and apoptosis. PLK4-IN-5 has anti proliferative activity against MCF-7 cells (IC50 = 0.48 μM) . PLK4-IN-5 can be used in the research of cancer such as breast cancer[1].

Product Specifications

UNSPSC

12352005

Target

Apoptosis; Polo-like Kinase (PLK)

Related Pathways

Apoptosis; Cell Cycle/DNA Damage

Field of Research

Cancer

Smiles

NC1=CC=C(C=C1)SC2=NC(NC3=CC=C(C=C3)NC4CCS(=O)(CC4)=O)=NC=C2Cl

Molecular Formula

C21H22ClN5O2S2

Molecular Weight

476.01

References & Citations

[1]Mu S, et al. Design, synthesis, and biological evaluation of 5-chlorine-2-amino-pyrimidine derivatives as potent PLK4 inhibitors. RSC Med Chem. 2025 Aug 14.