Multi-target kinase-IN-8

Multi-target kinase-IN-8 is an anti-cancer agent. Multi-target kinase-IN-8 exhibits inhibitory activity against various protein kinases (B-Raf V600E (IC50 = 0.078 µg/mL), c-Met (IC50 = 0.405 µg/mL), Pim-1 (IC50 = 1.053 µg/mL), EGFR WT (IC50 = 0.177 µg/mL), VEGFR-2 (IC50 = 0.275 µg/mL) ) . Multi-target kinase-IN-8 can induce cell cycle arrest and promote early and late apoptosis. Multi-target kinase-IN-8 is commonly used in cancer research[1].

Product Specifications

UNSPSC

12352005

Target

Apoptosis; c-Met/HGFR; EGFR; Pim; Raf; VEGFR

Related Pathways

Apoptosis; JAK/STAT Signaling; MAPK/ERK Pathway; Protein Tyrosine Kinase/RTK

Field of Research

Cancer

Smiles

N1(C2=CC=CC=C2)N=C(C3=CC4=CC=CC=C4O3)C(C5CC(C6=NC7=CC=CC=C7N6)=NN5)=C1

Molecular Formula

C27H20N6O

Molecular Weight

444.49

References & Citations

[1]Abd El-Karim SS, et al. Design, synthesis, and in silico studies of new benzofuran-pyrazole hybrids as multi-kinase inhibitors with potential antiproliferative activity. RSC Adv. 2025 Oct 1;15 (42) :35003-35021.