Multi-target kinase-IN-8
Multi-target kinase-IN-8 is an anti-cancer agent. Multi-target kinase-IN-8 exhibits inhibitory activity against various protein kinases (B-Raf V600E (IC50 = 0.078 µg/mL), c-Met (IC50 = 0.405 µg/mL), Pim-1 (IC50 = 1.053 µg/mL), EGFR WT (IC50 = 0.177 µg/mL), VEGFR-2 (IC50 = 0.275 µg/mL) ) . Multi-target kinase-IN-8 can induce cell cycle arrest and promote early and late apoptosis. Multi-target kinase-IN-8 is commonly used in cancer research[1].
Product Specifications
UNSPSC
12352005
Target
Apoptosis; c-Met/HGFR; EGFR; Pim; Raf; VEGFR
Related Pathways
Apoptosis; JAK/STAT Signaling; MAPK/ERK Pathway; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Smiles
N1(C2=CC=CC=C2)N=C(C3=CC4=CC=CC=C4O3)C(C5CC(C6=NC7=CC=CC=C7N6)=NN5)=C1
Molecular Formula
C27H20N6O
Molecular Weight
444.49
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
B-Raf; EGFR/ErbB1/HER1; Met; PIM1; VEGFR2/KDR/Flk-1
Frequently Asked Questions
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