SARS-CoV-2 nsp14-IN-8
SARS-CoV-2 nsp14-IN-8 (Compound 26) is a SARS-CoV-2 nsp14 inhibitor, with an IC50 of 53 nM. SARS-CoV-2 nsp14-IN-8 shows IC50 values of 170 nM, 8 nM, 21 nM against SARS-CoV-1 nsp14, HCoV-NL63 nsp14, HCoV-229E nsp14, respectively. SARS-CoV-2 nsp14-IN-8 can be used in the research of Coronavirus infection[1].
Product Specifications
UNSPSC
12352005
Target
SARS-CoV
Related Pathways
Anti-infection
Applications
COVID-19-anti-virus
Field of Research
Infection
Smiles
O[C@H]1[C@H](N2C(N=CN=C3N)=C3N=C2)C[C@H](CSC4=NC5=C(S4)C=CC=C5)[C@H]1O
Molecular Formula
C18H18N6O2S2
Molecular Weight
414.50
References & Citations
[1]Georgiou I, et al. Crystallographic characterisation and development of bi-substrate inhibitors of coronavirus nsp14 methyltransferase. bioRxiv, 2025: 2025.09. 30.679521.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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