AVI-6451
AVI-6451 is a novel orally effective SARS-CoV-2 Mac1 (IC50 = 28 nM) inhibitor. AVI-6451 can reduce viral load. AVI-6451 can be used for research on viral infections[1].
Product Specifications
UNSPSC
12352005
Target
SARS-CoV
Related Pathways
Anti-infection
Field of Research
Infection
Smiles
O=C1OCC(C)(C)N1NC2=C3C(NC4=C3C=C(F)C=C4C5CC5)=NC=N2
Molecular Formula
C18H18FN5O2
Molecular Weight
355.37
References & Citations
[1]Jaishankar P, et al. Discovery of AVI-6451, a Potent and Selective Inhibitor of the SARS-CoV-2 ADP-Ribosylhydrolase Mac1 with Oral Efficacy in vivo[J]. bioRxiv, 2025: 2025.10. 11.681833.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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