PROTAC BTK/IKZF1/3 Degrader-1

PROTAC BTK/IKZF1/3 Degrader-1 is a selective and orally active BCL6 and IKZF1/3 PROTAC degrader. PROTAC BTK/IKZF1/3 Degrader-1 exhibits antitumor activity. PROTAC BTK/IKZF1/3 Degrader-1 can be used for the research of cancer, such as lymphoma[1]. (Structure Note: Pink: BCL6/IKZF1/3 ligand (HY-179076) ; Blue: CRBN ligand (HY-41547) )

Product Specifications

CAS Number

[2416130-49-7]

UNSPSC

12352005

Target

Btk; IKZF Family; PROTACs

Related Pathways

Immunology/Inflammation; PROTAC; Protein Tyrosine Kinase/RTK

Field of Research

Cancer

Smiles

CN1CCN(C1=O)[C@@H]2CCCN(C2)C3=CN=C(C(NC4=CC=C(C=C4)C5CCN(CC5)CC6CCN(C6)C7=CC8=C(C(N(C8=O)C9CCC(NC9=O)=O)=O)C=C7)=N3)C(N)=O

Molecular Formula

C43H51N11O6

Molecular Weight

817.94

References & Citations

[1]Jin Y, et al. Modular PROTAC/IMiD Bifunctional Molecule Design for the Degradation of Synergistic Targets in the Treatment of Lymphoma. J Med Chem. 2025 Oct 23;68 (20) :21249-21281.