BTK/IKZF1/3 ligand 1

BTK/IKZF1/3 ligand 1 is a BTK/IKZF1/3 PROTAC ligand. BTK/IKZF1/3 ligand 1 can be conjugated with E3 ligase Ligand (HY-41547) and linker to synthesize PROTAC BTK/IKZF1/3 Degrader-1 (HY-179077) . PROTAC BTK/IKZF1/3 Degrader-1 can be used for cancer research[1].

Product Specifications

CAS Number

[1791402-90-8]

UNSPSC

12352005

Target

Btk; IKZF Family; Ligands for Target Protein for PROTAC

Related Pathways

Immunology/Inflammation; PROTAC; Protein Tyrosine Kinase/RTK

Field of Research

Cancer

Smiles

CN1CCN(C1=O)[C@@H]2CCCN(C2)C3=CN=C(C(Cl)=N3)C#N

Molecular Formula

C14H17ClN6O

Molecular Weight

320.78

References & Citations

[1]Jin Y, et al. Modular PROTAC/IMiD Bifunctional Molecule Design for the Degradation of Synergistic Targets in the Treatment of Lymphoma. J Med Chem. 2025 Oct 23;68 (20) :21249-21281.