BTK/IKZF1/3 ligand 1
BTK/IKZF1/3 ligand 1 is a BTK/IKZF1/3 PROTAC ligand. BTK/IKZF1/3 ligand 1 can be conjugated with E3 ligase Ligand and linker to synthesize PROTAC BTK/IKZF1/3 Degrader-1 (HY-179077). PROTAC BTK/IKZF1/3 Degrader-1 can be used for cancer research[1].
Product Specifications
CAS Number
1791402-90-8
UNSPSC
12352005
Target
Btk; IKZF Family; Ligands for Target Protein for PROTAC
Related Pathways
Immunology/Inflammation; PROTAC; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Smiles
CN1CCN(C1=O)[C@@H]2CCCN(C2)C3=CN=C(C(Cl)=N3)C#N
Molecular Formula
C14H17ClN6O
Molecular Weight
320.78
References & Citations
[1]Jin Y, et al. Modular PROTAC/IMiD Bifunctional Molecule Design for the Degradation of Synergistic Targets in the Treatment of Lymphoma. J Med Chem. 2025 Oct 23;68 (20) :21249-21281.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
IKZF1; IKZF3
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