Anticancer agent 280

Anticancer agent 280 (Compound 65) is an anti-cancer agent targeting triple-negative breast cancer (TNBC) . Anticancer agent 280 exhibits IC50 values of Anticancer agent 280 for MDA-MB-231, MDA-MB-231/LM2-4, Jurkat, and MCF-7 of 7.1, 11.65, 6.99, and 21.51 μM respectively. Anticancer agent 280 can cause significant arrest of cells in the S phase and induce cell apoptosis. Anticancer agent 280 can be used for the study of TNBC[1].

Product Specifications

UNSPSC

12352005

Target

Apoptosis

Related Pathways

Apoptosis

Field of Research

Cancer

Smiles

O=C(C1=CN(C2=C(C1=O)C=C(C=C2)OC3=CC=CC=C3)CC4=CC=C(C=C4)C(F)(F)F)NCC5=CC=CC=C5

Molecular Formula

C31H23F3N2O3

Molecular Weight

528.52

References & Citations

[1]Azzman N, et al. Novel 4-quinolone derivative inflicted cytotoxicity via intrinsic apoptotic pathway activation on human metastatic triple-negative breast cancer cells. Bioorg Chem. 2025 Oct;165:109033.