Anti-MRSA agent 40

Anti-MRSA agent 40 (Compound 7-8) is a potent agent against Methicillin-resistant Staphylococcus aureus (MRSA) . Anti-MRSA agent 40 exhibits significant antibacterial activity against MRSA2 and S. aureus ATCC 29213, with its MIC values being 1 μg/mL. Anti-MRSA agent 40 causes depolarization of the cell membrane, damages membrane integrity, and simultaneously increases the level of ROS within MRSA2, ultimately leading to cell lysis and death. Anti-MRSA agent 40 shows significant efficacy in the MRSA2 skin abscess model. Anti-MRSA agent 40 can be used for research on anti-MRSA infections[1].

Product Specifications

UNSPSC

12352005

Target

Bacterial; Reactive Oxygen Species (ROS)

Related Pathways

Anti-infection; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Applications

COVID-19-immunoregulation

Field of Research

Infection

Smiles

O=C(O)C1=CC=C(/C=N\NC(CCCOC2=CC(OC(C=C(OC(C)(C)C=C3)C3=C4O)=C4C5=O)=C5C(C/C=C(C)/C)=C2OC)=O)C=C1

Molecular Formula

C36H36N2O9

Molecular Weight

640.68

References & Citations

[1]Tang Q, et al. Discovery of antibacterial and synergistic acylhydrazone functionalized α-mangostin derivatives against drug-resistant pathogens. Bioorg Chem. 2025 Oct 14;166:109108.