PROTAC DAPK1 Degrader-1
PROTAC DAPK1 Degrader-1 (Compound CP1) is a DAPK1 PROTAC degrader with a DC50 of 119.6 nM. PROTAC DAPK1 Degrader-1 significantly increased the MDM2 protein level. PROTAC DAPK1 Degrader-1 significantly reduced the levels of cleaved caspase-3 and cleaved PARP in a cell apoptosis model induced by the neurotoxin ceramide, indicating that it effectively inhibits neuronal apoptosis by degrading DAPK1. PROTAC DAPK1 Degrader-1 can be used to study neurological diseases such as cerebral ischemia and traumatic brain injury (pink: DAPK1 ligand (HY-179071) ; blue: CRBN ligand (HY-10984) ; black: linker (HY-40171) ) [1].
Product Specifications
CAS Number
[3063030-38-3]
UNSPSC
12352005
Target
DAPK; PROTACs
Related Pathways
Apoptosis; PROTAC
Field of Research
Neurological Disease
Smiles
O=C(C1=CC=CC(N2N=CC3=C2N=C(NC3=O)SC(C(N)=O)C)=C1)NCCNC4=CC=CC(C(N5C(C(N6)=O)CCC6=O)=O)=C4C5=O
Molecular Formula
C30H27N9O7S
Molecular Weight
657.66
References & Citations
[1]Wu X, et al. Design, synthesis, and biological evaluation of death-associated protein kinase 1 PROTACs. Bioorg Chem. 2025 Oct;165:109044.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Cereblon; DAPK1
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