P2Y12/PDE5-IN-1

P2Y12/PDE5-IN-1 (Compound 10) is a dual-target inhibitor of P2Y12 (IC50 = 0.271 μg/mL) and PDE5 (IC50 = 0.154 μg/mL) . P2Y12/PDE5-IN-1 can be used for research on anti-thrombosis and vasodilation[1].

Product Specifications

UNSPSC

12352005

Target

P2Y Receptor; Phosphodiesterase (PDE)

Related Pathways

GPCR/G Protein; Metabolic Enzyme/Protease

Field of Research

Cardiovascular Disease

Smiles

O=C1N(C2CCCCC2)C(C=C(/N=C\C3=CC=C(Cl)C=C3Cl)N1C4CCCCC4)=O

Molecular Formula

C23H27Cl2N3O2

Molecular Weight

448.39

References & Citations

[1]Elsayed DA, et al. Antiplatelet therapy through inhibition of P2Y12 and phosphodiesterase receptors by novel synthesis 1,3-dicyclohexylpyrimidine-2,4 (1H,3H) -dione derivatives with computational evaluation. Bioorg Chem. 2025 Oct;165:109009.