Apoptosis inducer 50

Apoptosis inducer 50 (Compound 5e) is an apoptosis inducer as well as an autophagy inducer agent. Apoptosis inducer 50 exhibits potent and selective anti-cancer activity against triple-negative breast cancer cells and metastatic colon cancer cells. Apoptosis inducer 50 upregulates the expression of pro-apoptotic proteins (Bax, Bim, cleaved Caspase-9) and downregulates the expression of the anti-apoptotic protein (BCL-XL) . Apoptosis inducer 50 upregulates key autophagy markers such as Beclin-1 and ATG5, and enhances the conversion of LC3-I to LC3-II., Apoptosis inducer 50 arrests cancer cells in the G1/S phase by upregulating the expression of p21 and p27 while downregulating Cyclin D1. Apoptosis inducer 50 increases the level of ROS[1].

Product Specifications

UNSPSC

12352005

Target

Apoptosis; Atg7; Atg8/LC3; Autophagy; Bcl-2 Family; Caspase; CDK; Reactive Oxygen Species (ROS)

Related Pathways

Apoptosis; Autophagy; Cell Cycle/DNA Damage; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Field of Research

Cancer

Smiles

OC1=CC=CC=C1C2=NC(C3=CC=CC=C3O)=NN2C4=CC=C(C(N/N=C/C5=CC(/N=N/C6=CC=C([N+]([O-])=O)C=C6)=CC=C5O)=O)C=C4

Molecular Formula

C34H24N8O6

Molecular Weight

640.60

References & Citations

[1]Dilek Ö, et al. Structure-activity optimization of Deferasirox-derived aroyl hydrazones: Synthesis, DFT characterization, and mechanistic insights into selective anticancer activity against colon and breast cancer. Bioorg Chem. 2025 Oct;165:109061.