EGFR/tubulin-IN-1

EGFR/tubulin-IN-1 (Compound 26) is a dual-target inhibitor of EGFR and tubulin. EGFR/tubulin-IN-1 significantly reduces the levels of p-EGFR, p-AKT, and p-ERK in cells, disrupting the microtubule structure of the cells. EGFR/tubulin-IN-1 significantly inhibits the proliferation of H1975 cells and significantly blocks the cells in the G2/M phase. EGFR/tubulin-IN-1 induces the expression of autophagy markers LC3B-II and Beclin-1, while down-regulating the expression of p62. EGFR/tubulin-IN-1 induces ferroptosis, with increased ROS content and depletion of glutathione (GSH) . EGFR/tubulin-IN-1 inhibits epithelial-mesenchymal transition (EMT) and tumor metastasis. EGFR/tubulin-IN-1 has a significant tumor-suppressing effect in the H1975 transplanted tumor nude mouse model. EGFR/tubulin-IN-1 can be used for the study of non-small cell lung cancer[1].

Product Specifications

UNSPSC

12352005

Target

Akt; Atg8/LC3; Autophagy; EGFR; ERK; Ferroptosis; Microtubule/Tubulin; p62; Reactive Oxygen Species (ROS)

Related Pathways

Apoptosis; Autophagy; Cell Cycle/DNA Damage; Cytoskeleton; Immunology/Inflammation; JAK/STAT Signaling; MAPK/ERK Pathway; Metabolic Enzyme/Protease; NF-κB; PI3K/Akt/mTOR; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

Field of Research

Cancer

Smiles

O=C(NC1=CC2=C(NC3=CC=C(F)C(Cl)=C3)N=CN=C2C=C1)CCCCCCC(NC4=CC(CCC5=CC(OC)=C(OC)C(OC)=C5)=CC=C4OC)=O

Molecular Formula

C40H43ClFN5O6

Molecular Weight

744.25

References & Citations

[1]Wang X, et al. Discovery of the erianin derivatives as EGFR/tubulin dual-target inhibitors that suppress the proliferation and invasion of non-small cell lung cancer through autophagy-dependent ferroptosis. Bioorg Chem. 2025 Oct 15;166:109110.