VEGFR-2-IN-78

VEGFR-2-IN-78 (Compound 6b) is a potent VEGFR-2 inhibitor with an IC50 of 0.21 μM. VEGFR-2-IN-78 exhibits selective cytotoxicity against A-498 and MDA-MB-231 cells. VEGFR-2-IN-78 has antioxidant activity. VEGFR-2-IN-78 can be used in anti-angiogenesis research[1].

Product Specifications

UNSPSC

12352005

Target

VEGFR

Related Pathways

Protein Tyrosine Kinase/RTK

Field of Research

Cancer

Smiles

CC1=C(C(N/N=C/C2=CC=CC=C2)=O)S/C(N1C3=CC=CC=C3)=N/C4=NC5=CC=CC=C5S4

Molecular Formula

C25H19N5OS2

Molecular Weight

469.58

References & Citations

[1]Mohamed FAAA, et al. Design, synthesis, and computational validation of novel benzothiazole derivatives as dual anticancer-antioxidant agents targeting VEGFR-2. Bioorg Chem. 2025 Oct 15;166:109066.