ERα degrader 14
ERα degrader 14 (Compound B7) is a potent ERα degrader. ERα degrader 14 exhibits significantly potent and selective anti-proliferative activity on two ERα-positive breast cancer cell lines (MCF-7 and T47D) . ERα degrader 14 induces cell cycle arrest, inhibits cell migration, and induces cell apoptosis. ERα degrader 14 effectively inhibits tumor growth in mouse models. ERα degrader 14 can be used for the study of breast cancer[1].
Product Specifications
CAS Number
2991580-03-9
UNSPSC
12352005
Target
Apoptosis; Estrogen Receptor/ERR
Related Pathways
Apoptosis; Vitamin D Related/Nuclear Receptor
Field of Research
Cancer
Smiles
OC1=CC=C2C(SC(C3=CC=C(O)C=C3)=C2C(C4=CC=C(O[C@@H]5CCN(C(C(Cl)C)=O)C5)C=C4)=O)=C1
Molecular Formula
C28H24ClNO5S
Molecular Weight
522.01
References & Citations
[1]Tian Y, et al. Rational design, synthesis, and biological evaluation of Raloxifene-based potent degrader of estrogen receptor alpha. Bioorg Chem. 2025 Oct 15;166:109063.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
ERα
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