EGFR-IN-183
EGFR-IN-183 (Compound 5q) is an EGFR inhibitor. EGFR-IN-183 strongly binds to EGFR (T790M/L858R) mutants. EGFR-IN-183 exhibits anti-proliferative activity against MDA-MB-231, with an IC50 value of 16.4 μM. EGFR-IN-183 can be used for research on triple-negative breast cancer[1].
Product Specifications
UNSPSC
12352005
Target
EGFR
Related Pathways
JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Smiles
O=C(N/N=C/C1=CN(C2=CC=CC=C12)S(=O)(C3=CC=C(C=C3)C)=O)C4=C(O)C=C(C=CC=C5)C5=C4
Molecular Formula
C27H21N3O4S
Molecular Weight
483.54
References & Citations
[1]Ghaffar U, et al. In-vitro and in-silico study to assess anti breast cancer potential of N-tosyl-indole based hydrazones. Sci Rep. 2025 Oct 13;15 (1) :35733.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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