APG-7

APG-7 binds to the TLR4/MD-2 interface, thereby inhibiting NO production (IC50 of 24.2 μg/mL) . APG-7 is an Apigenin (HY-N1201) derivative. APG-7 has low toxicity to the 3T3 fibroblast cell line. APG-7 can be used for the study of oxidative stress and inflammation[1].

Product Specifications

UNSPSC

12352005

Target

Toll-like Receptor (TLR)

Related Pathways

Immunology/Inflammation

Field of Research

Cancer; Metabolic Disease; Inflammation/Immunology

Smiles

O[C@@H]1[C@@H](OC2=CC=C(C=C2)C3=CC(C4=C(C=C(C=C4O3)O)O)=O)O[C@@H](COC(/C=C/C5=CC=C(C=C5)O)=O)[C@H](O)[C@@H]1O

Molecular Formula

C30H26O12

Molecular Weight

578.52

References & Citations

[1]Soomro S, et al. Apigenin and its derivative modulate nitric oxide production and interfere with TLR4-M2: In-vitro and in-silico insights. Bioorg Chem. Published online October 4, 2025.