Nur77 antagonist 2
Nur77 antagonist 2 (Compound 12b) is an orally active Nur77 antagonist with a KD value of 0.42 μM. Nur77 antagonist 2 exhibits proliferative activity on liver cancer cells. Nur77 antagonist 2 stabilizes Nur77 by inhibiting its ubiquitin-proteasomal degradation, leading to Nur77-dependent apoptosis via the ASK1-JNK/p38 pathway. Nur77 antagonist 2 inhibits tumor growth in the HCCLM3 xenograft model. Nur77 antagonist 2 can be used for the study of hepatocellular carcinoma (HCC) [1].
Product Specifications
UNSPSC
12352005
Target
Apoptosis; ASK1; JNK; Nuclear Hormone Receptor 4A/NR4A; p38 MAPK
Related Pathways
Apoptosis; MAPK/ERK Pathway; Vitamin D Related/Nuclear Receptor
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
O=C(N/N=C/C1=CC(C)=CC=C1)C(N2)=CC3=C2C=CC(NC4=NC=CC(C5=CC=NC=C5)=N4)=C3
Molecular Formula
C26H21N7O
Molecular Weight
447.49
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Nur77/NR4A1
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