VEGFR-2-IN-77
VEGFR-2-IN-77 (Compound 10) is a VEGFR-2 inhibitor with an IC50 value of 139 nM. VEGFR-2-IN-77 inhibits the PI3K/AKT/mTOR pathway. VEGFR-2-IN-77 exhibits selective cytotoxicity, being particularly sensitive to leukemia and prostate cancer cells. VEGFR-2-IN-77 causes cell cycle arrest and apoptosis, inhibiting cell migration and invasion. VEGFR-2-IN-77 can be used for the study of leukemia and prostate cancer.
Product Specifications
CAS Number
[169205-26-9]
Target
Akt; Apoptosis; mTOR; PI3K; VEGFR
Related Pathways
Apoptosis; PI3K/Akt/mTOR; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Smiles
O=C1C(C)=NC2=CC=CC=C2N1CC(N/N=C3C(C=CC=C4)=C4NC/3=O)=O
Molecular Formula
C19H15N5O3
Molecular Weight
361.35
References & Citations
[1]Abdelall EKA, et al. Novel quinoxaline derivatives as promising cytotoxic agents: structure-based design, in silico studies, VEGFR-2 inhibition, and PI3K/AKT/mTOR pathway modulation. Bioorg Chem. 2025 Oct 19;166:109116.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
VEGFR2/KDR/Flk-1
Curated Selection
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