EGFR/VEGFR2-IN-7
EGFR/VEGFR2-IN-7 (Compound 3e) is a dual-target EGFR/VEGFR2 inhibitor, with IC50 values of 142 (EGFR) and 71 nM (VEGFR2) . EGFR/VEGFR2-IN-7 exhibits broad-spectrum and potent anti-proliferative activity, especially being sensitive to breast cancer. EGFR/VEGFR2-IN-7 induces cell cycle arrest and apoptosis, inhibits cell migration and invasion. EGFR/VEGFR2-IN-7 can be used for research on breast cancer[1].
Product Specifications
UNSPSC
12352005
Target
Apoptosis; EGFR; VEGFR
Related Pathways
Apoptosis; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
O=C(C)N1C(C2=CC=C(OC)C=C2)CC(C(C=C3)=CC=C3OCC4=CC=CC=C4)=N1
Molecular Formula
C25H24N2O3
Molecular Weight
400.47
References & Citations
[1]Sawiris MM, et al. Design, synthesis and biological evaluation of novel pyrazoline derivatives as dual EGFR/VEGFR-2 inhibitors for targeted cancer therapy. Bioorg Chem. 2025 Oct;165:109075.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
EGFR/ErbB1/HER1; VEGFR2/KDR/Flk-1
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