RNA polymerase-IN-4
RNA polymerase-IN-4 is a RNA polymerase inhibitor with an EC50 of 22.81 nM. RNA polymerase-IN-4 exhibits potent anti-influenza virus activity (EC50 = 3.76 nM), relatively low cytotoxicity (CC50 = 29.91 μM) . RNA polymerase-IN-4 can be used for the research of infection, such as influenza virus infection[1].
Product Specifications
CAS Number
[3040910-48-0]
Target
DNA/RNA Synthesis; Influenza Virus
Related Pathways
Anti-infection; Cell Cycle/DNA Damage
Field of Research
Infection
Smiles
FC1=C(F)C=CC2=C1CSC3=C(C=CC=C3)[C@H]2N4[C@@H](CC5(CCOCC5)C6)N6C(C(N4C=C7)=C(O)C7=O)=O
Molecular Formula
C28H25F2N3O4S
Molecular Weight
537.58
References & Citations
[1]He J, et al. Discovery of a spirocyclic influenza RNA-dependent RNA polymerase inhibitor. Bioorg Chem. 2025 Oct 17;166:109109.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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