HCA-6

HCA-6 is a calcium-channel and P-glycoprotein blocker. HCA-6 can induce cancer cells apoptosis and increase anticancer activity of Cisplatin (HY-17394) . HCA-6 also exhibits antibacterial activity against Bacillus subtilis. HCA-6 can be used for the research of cancer and infection, such as breast cancer[1].

Product Specifications

UNSPSC

12352005

Target

Apoptosis; Bacterial; Calcium Channel; P-glycoprotein

Related Pathways

Anti-infection; Apoptosis; Membrane Transporter/Ion Channel; Neuronal Signaling

Field of Research

Cancer; Infection

Smiles

O[C@@H]1[C@H](O)[C@@H](COC(COC2=CC=C(C3C(C(OCC)=O)=C(C)NC(C)=C3C(OCC)=O)C=C2[N+]([O-])=O)=O)O[C@H]1N(C(N4)=O)C=C(F)C4=O

Molecular Formula

C30H33FN4O14

Molecular Weight

692.60

References & Citations

[1]Chen G, et al. Novel dihydropyridines as potential calcium-channel and P-glycoprotein blockers applicable for chemotherapy sensitization. Bioorg Chem. 2025 Oct;165:109072.