NP3-742
NP3-742 is an orally active NLRP3 inhibitor that binds to the NLRP3 NACHT domain. NP3-742 inhibits IL-1β release with IC50s of 6 nM and 47 nM in both the cellular and whole blood assays, respectively. NP3-742 is highly selective against a panel of more than 50 enzymes, receptors and sodium and calcium channels. NP3-742 can be used for the study of gout, cardiovascular disease or osteoarthritis[1].
Product Specifications
Target
Interleukin Related; NOD-like Receptor (NLR)
Related Pathways
Immunology/Inflammation
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Inflammation/Immunology; Cardiovascular Disease; Metabolic Disease
Smiles
CC1=CC2=C(N1)N=C(C=C2)C3=C(C=C(N=N3)N[C@@H]4CCCN(C4)C)C
Molecular Formula
C19H24N6
Molecular Weight
336.43
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
IL-1; NLRP3
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