CDK9-IN-45
CDK9-IN-45 (Compound B11) is a highly selective CDK9 inhibitor with IC50 values for CDK9 and CDK1 of 7.13 and 489.5 nM respectively. CDK9-IN-45 exhibits a potent inhibitory effect on colorectal cancer cells. CDK9-IN-45 induces cell apoptosis and leads to significant accumulation of ROS. CDK9-IN-45 activates Caspase-3, downregulates Mcl-1, XIAP, and c-Myc. CDK9-IN-45 can be used for research on colorectal cancer[1].
Product Specifications
Target
Apoptosis; Bcl-2 Family; Caspase; CDK; c-Myc; IAP; Reactive Oxygen Species (ROS)
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Field of Research
Cancer
Smiles
FC1=CC=C(C2=CC=NC(NC3=CC(NN=C4C(N5CC6(COC6)C5)=O)=C4C=C3)=C2)C(OC)=C1
Molecular Formula
C25H22FN5O3
Molecular Weight
459.47
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Caspase 3; CDK1; CDK9; Mcl-1; XIAP
Frequently Asked Questions
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