CAIX/CDK-2-IN-1

CAIX/CDK-2-IN-1 is a dual-acting inhibitor of carbonic anhydrase IX (CA IX) and cyclin-dependent kinase-2 (CDK-2) with IC50 values of 0.29 μM and 0.32 μM. The zein nanoparticls of CAIX/CDK-2-IN-1 can induce cancer cells apoptosis. CAIX/CDK-2-IN-1 can be used for the research of cancer, such as lung cancer[1].

Product Specifications

UNSPSC

12352005

Target

Apoptosis; Bcl-2 Family; Carbonic Anhydrase; Caspase; CDK; MDM-2/p53

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Smiles

ClC1=CC=C(C2=NC(N=C(SCC(NC3=CC=C(S(=O)(N)=O)C=C3)=O)NC4=O)=C4C(C5=CC=CS5)=C2)C=C1

Molecular Formula

C25H18ClN5O4S3

Molecular Weight

584.09

References & Citations

[1]Abosalim HM, et al. Innovative design and synthesis of dual-acting hCA IX/CDK-2 inhibitors through hetero ring fused pyrimidine utilization for cutting-edge anticancer therapy: Zein nanoparticles for in vivo lung cancer treatment. Bioorg Chem. 2025 Oct 5;166:109057.