COX-2/15-LOX-IN-7
COX-2/15-LOX-IN-7 is a potent, selective and orally active dual inhibitor of COX-2 and 15-LOX with IC50 values of 0.022 and 1.19 μM. COX-2/15-LOX-IN-7 also inhibits COX-1 with an IC50 value of 28.081μM. COX-2/15-LOX-IN-7 has low cytotoxicity against human colorectal cancer HT-29 and HCT116 cell lines (IC50 >100 μM for both) . COX-2/15-LOX-IN-7 exhibits non-ulcerogenic performance. COX-2/15-LOX-IN-7 can be used for the research of cancer[1].
Product Specifications
CAS Number
1860810-23-6
UNSPSC
12352005
Target
COX; Lipoxygenase
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
FC(F)(F)C(C=C1)=CC=C1C(CC(C2=CC=CC=C2)=N3)N3C4=CC=CC=C4
Molecular Formula
C22H17F3N2
Molecular Weight
366.38
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
15-LOX; COX-1; COX-2
Frequently Asked Questions
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