COX-2/15-LOX-IN-7

COX-2/15-LOX-IN-7 is a potent, selective and orally active dual inhibitor of COX-2 and 15-LOX with IC50 values of 0.022 and 1.19 μM. COX-2/15-LOX-IN-7 also inhibits COX-1 with an IC50 value of 28.081μM. COX-2/15-LOX-IN-7 has low cytotoxicity against human colorectal cancer HT-29 and HCT116 cell lines (IC50 >100 μM for both) . COX-2/15-LOX-IN-7 exhibits non-ulcerogenic performance. COX-2/15-LOX-IN-7 can be used for the research of cancer[1].

Product Specifications

CAS Number

[1860810-23-6]

UNSPSC

12352005

Target

COX; Lipoxygenase

Related Pathways

Immunology/Inflammation; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

FC(F)(F)C(C=C1)=CC=C1C(CC(C2=CC=CC=C2)=N3)N3C4=CC=CC=C4

Molecular Formula

C22H17F3N2

Molecular Weight

366.38

References & Citations

[1]Abdullah D, et al. Pioneering 1,3,5-triaryl pyrazolines as promising dual inhibitors of COX-2 and 15-LOX endowed with potent anticancer activity: design, synthesis, and in silico study. Bioorg Chem. 2025 Oct 12;166:109081.