HDAC-IN-94

HDAC-IN-94 is a potent, selective HDAC6 inhibitor (IC50 = 4.5 nM) . HDAC-IN-94 shows >1000-fold selectivity over HDAC8 and shows minimal activity against other isoforms (HDAC1-3/10) . HDAC-IN-94 induces α-tubulin hyperacetylation, apoptosis, and G2/M cell cycle arrest, exhibiting potent anti-tumor efficacy with low cytotoxicity. HDAC-IN-94 can be used for neuroblastoma and glioblastoma research[1].

Product Specifications

UNSPSC

12352005

Target

Apoptosis; Caspase; HDAC; Microtubule/Tubulin

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton; Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer; Neurological Disease

Smiles

O=C(NCC1=CC=C(C(NO)=O)C=C1)/C=C/C2=CC(OC)=C(O)C=C2

Molecular Formula

C18H18N2O5

Molecular Weight

342.35

References & Citations

[1]Cursaro I, et al. New Vanillyl-capped HDAC inhibitors exhibit anti-tumor efficacy in neuroblastoma and glioblastoma cells. Bioorg Chem. 2025 Oct 14;166:109085.