Topoisomerase II-IN-25

Topoisomerase II-IN-25 (Compound 6a) is a selective inhibitor of topoisomerase II and has no inhibitory activity on topoisomerase I. Topoisomerase II-IN-25 exhibits significant anti-PC-3 cell activity. Topoisomerase II-IN-25 significantly increases intracellular ROS levels, inducing oxidative stress. Topoisomerase II-IN-25 causes depolarization of mitochondrial membrane potential and promotes cell apoptosis. Topoisomerase II-IN-25 blocks PC-3 cells in the G2/M phase. Topoisomerase II-IN-25 can be used for the study of prostate cancer[1].

Product Specifications

UNSPSC

12352005

Target

Apoptosis; Reactive Oxygen Species (ROS) ; Topoisomerase

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Field of Research

Cancer

Smiles

O=C(C1=C(OCC=C)C=C(C2=CC=C(Br)C=C2)C(N3CC=C)=C1C4=C3C=CC=C4)OC

Molecular Formula

C26H22BrNO3

Molecular Weight

476.36

References & Citations

[1]Maity P, et al. Hit-to lead optimization of new carbazoles as potential anticancer agents via targeting human topoisomerase II. Bioorg Chem. 2025 Oct 6;166:109070.