Ferroptosis/apoptosis inducer-3

Ferroptosis/apoptosis inducer-3 (Compound 34) is a Ferroptosis and Apoptosis inducer. Ferroptosis/apoptosis inducer-3 induces both Ferroptosis and Apoptosis by causing G2/M phase cell cycle arrest, disrupting mitochondrial membrane potentials, promoting lipid peroxidation, and increasing the levels of Ca2+ and Fe2+ through the activation of calcium/calmodulin signaling. Ferraplasm/apoptosis inducer-3 shows anticancer effects against cervical cancer, adenocarcinoma, breast cancer, colon cancer, and colorectal carcinoma[1].

Product Specifications

UNSPSC

12352005

Target

Apoptosis; Calcium Channel; Ferroptosis; Mitochondrial Metabolism

Related Pathways

Apoptosis; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling

Field of Research

Cancer

Smiles

COC1=CC(C2=NC=CC3=NC(C4=CNC5=C4C(F)=CC=C5)=NN23)=CC(OC)=C1OC

Molecular Formula

C22H18FN5O3

Molecular Weight

419.41

References & Citations

[1]Chen L, et al. Dual Induction of Ferroptosis and Apoptosis by Triazolopyrimidinyl Derivatives: Design, Synthesis, and Biological Evaluation for Their Anticancer Efficacy via Calcium/Calmodulin Signaling and Mitochondrial Impairment. J Med Chem. 2025 Nov 13;68 (21) :23024-23049.