OGG1 activator-1
OGG1 activator-1 (Compound 30) is a selective 8-oxoguanine DNA glycosylase-1 (OGG1) activator with an AC50 value of 0.58 μM. OGG1 activator-1 does not activate nor inhibit the key downstream repair enzyme APE1, and shows > 150-fold selectivity for the activation effect on OGG1. OGG1 activator-1 exhibits extremely high metabolic stability and almost no cytotoxicity. OGG1 activator-1 can be used for the study of oxidative stress-related diseases (such as neurodegenerative diseases, fibrotic diseases, cancer, inflammation, etc.) [1].
Product Specifications
UNSPSC
12352005
Target
DNA Glycosylase
Related Pathways
Epigenetics
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Neurological Disease; Inflammation/Immunology
Smiles
OC1=CC2=C(NC(C3=CC=CN=C3)=C2CCN)C=C1
Molecular Formula
C15H15N3O
Molecular Weight
253.30
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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