CYP3A4-IN-6

CYP3A4-IN-6 (Compound 8a) is a CYP3A4 inhibitor with tissue-selective metabolism. CYP3A4-IN-6 remains stable in the intestinal S9 component but is rapidly metabolized in the liver S9 component, forming a less active metabolite. CYP3A4-IN-6 can be used for intestinal selectivity studies[1].

Product Specifications

UNSPSC

12352005

Target

Cytochrome P450

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Metabolic Disease

Smiles

O=C(C1=CC=C(C=C1)COCC2=CC=C(C=C2)N3C=CN=C3)OC

Molecular Formula

C19H18N2O3

Molecular Weight

322.36

References & Citations

[1]Elsayed DA, et al. Antiplatelet therapy through inhibition of P2Y12 and phosphodiesterase receptors by novel synthesis 1,3-dicyclohexylpyrimidine-2,4 (1H,3H) -dione derivatives with computational evaluation. Bioorg Chem. 2025 Oct;165:109009.