NOD2 agonist 4

NOD2 agonist 4 (Compound 12b) is a potent NOD2 agonist with an EC50 of 44.1 nM. NOD2 agonist 4 induces cytokine production (MCP-1, IL-6 and IL-8) in peripheral blood mononuclear cells (PBMCs), both alone and in combination with Lipopolysaccharide (LPS) (HY-D1056) . NOD2 agonist 4 can be used for the studies of NOD2-targeted immunomodulator or vaccine adjuvant[1].

Product Specifications

UNSPSC

12352211

Target

Interleukin Related; NOD-like Receptor (NLR)

Related Pathways

Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Smiles

[][Fe][].O=C(Cc1cccc1)NCC(N[C@@H](C(C)C)C(N[C@H](CCC(OCC)=O)C(OCC)=O)=O)=O.c2cccc2

Molecular Formula

C28H39FeN3O7

Molecular Weight

585.47

References & Citations

[1]Car Z, et al. Ferrocene-Containing Desmuramylpeptides Adopt A Flexible Conformation and Exhibit NOD2 Agonistic Activity. Organometallics. 2025 Oct 22.