(S) -5-HT2CR agonist 1

(S) -5-HT2CR agonist 1 (Compound (S) -16k) is selective 5-HT2CR agonist, with an EC50 of 14 nM. FXa-IN-2 can be used in the research of hyperlocomotion[1].

Product Specifications

CAS Number

[2841458-00-0]

UNSPSC

12352005

Target

5-HT Receptor

Related Pathways

GPCR/G Protein; Neuronal Signaling

Field of Research

Neurological Disease

Smiles

OC1=C(C2=C3[C@@]([H])(NCCC3=C1)CC4=C2C(Cl)=CC=C4)OC.Cl

Molecular Formula

C17H17Cl2NO2

Molecular Weight

338.23

References & Citations

[1]Qin W, et al. Discovery of New N-H Aporphine Derivatives As Brain-Penetrant Gq-Biased 5-HT2C Receptor Agonists and Dual 5-HT2C/5-HT2A Receptor Agonists. J Med Chem. 2025 Nov 13;68 (21) :23300-23323.