5-HT2CR agonist 2
5-HT2CR agonist 2 (Compound 16k) is a selective, blood-brain barrier-penetrating and Gq-biased 5-HT2CR agonist, with an EC50 of 36 nM. 5-HT2CR agonist 2 attenuates MK801 -induced hyperlocomotion and reverses Phencyclidine-induced hyperlocomotor activity[1].
Product Specifications
CAS Number
2841457-05-2
UNSPSC
12352005
Target
5-HT Receptor
Related Pathways
GPCR/G Protein; Neuronal Signaling
Field of Research
Neurological Disease
Smiles
COC1=C(C=C2C3=C1C4=C(CC3NCC2)C=CC=C4Cl)O.Cl
Molecular Formula
C17H17Cl2NO2
Molecular Weight
338.23
References & Citations
[1]Qin W, et al. Discovery of New N-H Aporphine Derivatives As Brain-Penetrant Gq-Biased 5-HT2C Receptor Agonists and Dual 5-HT2C/5-HT2A Receptor Agonists. J Med Chem. 2025 Nov 13;68 (21) :23300-23323.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
5-HT2 Receptor
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