MTOR/GLS1-IN-1

MTOR/GLS1-IN-1 is a potent dual targeted mTOR/GLS1 inhibitor. Has anti proliferative activity against various tumor cells, such as MDA-MB-231 (IC90 = 2.14 µM), MCF-7 (IC90 = 0.91 µM), SK-BR-3 (IC90 = 0.84 µM), and 4T1 (IC90 = 0.32 µM) cells. mTOR/GLS1-IN-1 dose dependently induces ROS accumulation, induces autophagosome formation, and induces apoptosis. mTOR/GLS1-IN-1 can increase Fe2+, decrease GPX4, and induce ferroptosis. mTOR/GLS1-IN-1 can inhibit cell migration, invasion, and angiogenesis. mTOR/GLS1-IN-1 can be used in the research of cancer, such as breast cancer[1].

Product Specifications

UNSPSC

12352005

Target

Apoptosis; Autophagy; Ferroptosis; Glutaminase; Glutathione Peroxidase; mTOR; Reactive Oxygen Species (ROS)

Related Pathways

Apoptosis; Autophagy; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; PI3K/Akt/mTOR

Field of Research

Cancer

Smiles

CO[C@@H](C[C@@H]1CC[C@H]([C@](C(C(N2[C@@H](CCCC2)C(O[C@@H](CC([C@@H](/C=C([C@@H](O)[C@H]3OC)\C)C)=O)[C@@H](C[C@@H]4CC[C@H]([C@@H](C4)OC)OC(CCCCCCC(NC5=CC=C(CCCCC6=NN=C(S6)NC(CC7=CC=CC=N7)=O)N=N5)=O)=O)C)=O)=O)=O)(O1)O)C)/C(C)=C/C=C/C=C/[C@H](C[C@H](C3=O)C)C

Molecular Formula

C76H108N8O16S

Molecular Weight

1421.78

References & Citations

[1]Wu L, et al. Design, Synthesis, and Biological Evaluation of Rapamycin Derivatives as the First Mammalian Target of Rapamycin and GLS1 Dual Inhibitors. J Med Chem. 2025 Nov 13;68 (21) :22959-22987.