NFE2L1 activator-1
NFE2L1 activator-1 is an efficient NFE2L1 activator (EC50 =2.4 µM) . NFE2L1 activator-1 can effectively resist ferroptosis. NFE2L1 activator-1 can specifically activate the NFE2L1 signaling pathway and upregulate GPX4. NFE2L1 activator-1 can be used for cancer research[1].
Product Specifications
CAS Number
[3070514-51-8]
Target
Ferroptosis; Glutathione Peroxidase
Related Pathways
Apoptosis; Metabolic Enzyme/Protease
Field of Research
Cancer
Smiles
COC1=C(OC)C=CC(/C=C2CC(NS(=O)(CC)=O)C/C(C\2=O)=C\C3=CC=C(OC)C(OC)=C3)=C1
Molecular Formula
C26H31NO7S
Molecular Weight
501.59
References & Citations
[1]Svobodová L, et al. Targeting NFE2L1 signalling with small molecules to protect against Ferroptosis. Bioorg Med Chem Lett. 2025 Oct 3;130:130425.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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