FLT3-IN-36
FLT3-IN-36 is a potent FLT3 inhibitor. FLT3-IN-36 exhibits antitumor activity against FLT3-mutated acute myeloid leukemia (AML) cells. FLT3-IN-36 induces cell cycle arrest, reduces mitochondrial membrane potential, and induces apoptosis, downregulating FLT3 and downstream protein expression (including AKT, ERK, PI3K, and STAT5) . FLT3-IN-36 can be used for AML research[1].
Product Specifications
Target
Akt; Apoptosis; ERK; FLT3; PI3K; STAT
Related Pathways
Apoptosis; JAK/STAT Signaling; MAPK/ERK Pathway; PI3K/Akt/mTOR; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Field of Research
Cancer
Smiles
O=C(C1CC1)C2=CC(C(C3=C(C(C)=O)C=CC=C3)=O)=C4C=CC=CN42
Molecular Formula
C21H17NO3
Molecular Weight
331.36
References & Citations
[1]Xing Q, et al. Development and bio-evaluation of novel indolizine derivatives in FLT3 mutant acute myeloid leukemia cells. Bioorg Med Chem Lett. 2025 Oct 4;130:130429.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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