BRAFV600E-IN-3

BRAFV600E-IN-3 (Compound AV05) is a BRAFV600E inhibitor with an IC50 value of 0.89 μM. BRAFV600E-IN-3 inhibits the proliferation of melanoma cells. BRAFV600E-IN-3 can be used for the study of melanoma[1].

Product Specifications

Target

Raf

Related Pathways

MAPK/ERK Pathway

Field of Research

Cancer

Smiles

O=S(C1=CC=CC=C1)(NC2=CC=C(C3NC(NC(C4=CC(Br)=CC=C4)=C3)=S)C=C2)=O

Molecular Formula

C22H18BrN3O2S2

Molecular Weight

500.43

References & Citations

[1]Singh AK, et al. Targeted design, synthesis, molecular simulation, ADME-T and in-vitro anticancer assessment of phenyl-substituted-thioxo-tetrahydro-pyrimidin-benzenesulfonamide derivatives as potential BRAFV600E/WT inhibitors. Bioorg Med Chem Lett. 2025 Oct 8;130:130431.