PI3K/AKT-IN-5
PI3K/AKT-IN-5 (Compound 3h) is a PI3K/AKT inhibitor. PI3K/AKT-IN-5 exhibits outstanding broad-spectrum anti-cancer activity, especially being sensitive to colorectal cancer. PI3K/AKT-IN-5 significantly reduces cell colony formation, induces G2/M phase cell cycle arrest and cell apoptosis. PI3K/AKT-IN-5 can be used for research on colorectal cancer[1].
Product Specifications
CAS Number
[3093148-10-5]
Target
Akt; Apoptosis; PI3K
Related Pathways
Apoptosis; PI3K/Akt/mTOR
Field of Research
Cancer
Smiles
O=S(/N=C1NC2=CC(OC)=CC=C2C\1=C/C3=CC=CC=C3)(C4=CC=C(C=C4)C)=O
Molecular Formula
C23H20N2O3S
Molecular Weight
404.48
References & Citations
[1]Wang CC, et al. Discovery of N-Ts-3-benzylidene-indolin-2-imines as potent anti-colorectal cancer agents through suppression of the PI3K-AKT pathway. Bioorg Med Chem Lett. 2025 Oct 11;130:130437.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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