WRN-IN-21
WRN-IN-21 (Compound 11b) is a WRN helicase inhibitor with pIC50 values for WRN and BLM helicases of 3.6 and 5.4 respectively. WRN-IN-21 can be used for the study of MSI-related cancers[1].
Product Specifications
Target
DNA/RNA Synthesis
Related Pathways
Cell Cycle/DNA Damage
Field of Research
Cancer
Smiles
FC1=CC=C(NC2=NN(C3CC3)C4=C2C=C(NC(CCl)=O)C=C4)C=C1
Molecular Formula
C18H16ClFN4O
Molecular Weight
358.80
References & Citations
[1]Smith GMT, et al. AI-assisted delivery of novel covalent WRN inhibitors from a non-covalent fragment screen. Bioorg Med Chem Lett. 2025 Sep 30;131:130421.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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