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WRN-IN-21

WRN-IN-21 (Compound 11b) is a WRN helicase inhibitor with pIC50 values for WRN and BLM helicases of 3.6 and 5.4 respectively. WRN-IN-21 can be used for the study of MSI-related cancers[1].

Product Specifications

Target

DNA/RNA Synthesis

Related Pathways

Cell Cycle/DNA Damage

Field of Research

Cancer

Smiles

FC1=CC=C(NC2=NN(C3CC3)C4=C2C=C(NC(CCl)=O)C=C4)C=C1

Molecular Formula

C18H16ClFN4O

Molecular Weight

358.80

References & Citations

[1]Smith GMT, et al. AI-assisted delivery of novel covalent WRN inhibitors from a non-covalent fragment screen. Bioorg Med Chem Lett. 2025 Sep 30;131:130421.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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