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SIRT6-IN-5

SIRT6-IN-5 is a selective and safe SIRT6 inhibitor (IC50 = 18.91 µM) . SIRT6-IN-5 can enhance the anti proliferative effect of chemotherapy drugs. SIRT6-IN-5 can be used in the research of cancer, such as breast cancer[1].

Product Specifications

Target

Sirtuin

Related Pathways

Cell Cycle/DNA Damage; Epigenetics

Field of Research

Cancer

Smiles

CCOC(CC1=CC=C(OC(C2=CC=C(NC(N)=N)C=C2)=O)C=C1)=O

Molecular Formula

C18H19N3O4

Molecular Weight

341.36

References & Citations

[1]Ma Y, et al. Design and synthesis of guanidino derivatives of benzoate esters as SIRT6 inhibitors. Bioorg Med Chem Lett. 2025 Oct 7;130:130430.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

SIRT6

Frequently Asked Questions

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