SIRT6-IN-5
SIRT6-IN-5 is a selective and safe SIRT6 inhibitor (IC50 = 18.91 µM) . SIRT6-IN-5 can enhance the anti proliferative effect of chemotherapy drugs. SIRT6-IN-5 can be used in the research of cancer, such as breast cancer[1].
Product Specifications
Target
Sirtuin
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Field of Research
Cancer
Smiles
CCOC(CC1=CC=C(OC(C2=CC=C(NC(N)=N)C=C2)=O)C=C1)=O
Molecular Formula
C18H19N3O4
Molecular Weight
341.36
References & Citations
[1]Ma Y, et al. Design and synthesis of guanidino derivatives of benzoate esters as SIRT6 inhibitors. Bioorg Med Chem Lett. 2025 Oct 7;130:130430.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
SIRT6
Curated Selection
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