SHP2-IN-45
SHP2-IN-45 is a potent, highly selective, and orally effective SHP2 allosteric inhibitor. SHP2-IN-45 significantly reduce the expression of IL-6, TNF-α, IL-1β, and iNOS mRNA. SHP2-IN-45 inhibits polarization of M1 macrophages. SHP2-IN-45 can inhibit the NF-κB pathway. SHP2-IN-45 can be used for research on sepsis and acute lung injury[1].
Product Specifications
CAS Number
2949435-53-2
UNSPSC
12352005
Target
Interleukin Related; NF-κB; NO Synthase; SHP2; TNF Receptor
Related Pathways
Apoptosis; Immunology/Inflammation; NF-κB; Protein Tyrosine Kinase/RTK
Field of Research
Inflammation/Immunology
Smiles
CC1=C2C([C@H](CCN(C3=NC=C(SC4=CC=NC(N)=C4Cl)N=C3)C2)N)=CC=C1
Molecular Formula
C20H21ClN6S
Molecular Weight
412.94
References & Citations
[1]Jiang W, et al. Discovery of Potent and Orally bioavailable Benzoazepinamine-Based SHP2 Allosteric Inhibitors for the Treatment of Inflammatory Diseases. J Med Chem. 2025 Oct 20.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
IL-1; IL-6; iNOS; NF-κB
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