Apelin agonist 2
Apelin agonist 2 is an orally effective APLNR agonist. Apelin agonist 2 can significantly inhibit the accumulation of cAMP (EC50 = 10 nM) . Apelin agonist 2 exhibits a significant improvement in glucose tolerance. Apelin agonist 2 can be used to study metabolic diseases such as diabetes[1].
Product Specifications
UNSPSC
12352005
Target
Apelin Receptor (APJ)
Related Pathways
GPCR/G Protein
Field of Research
Metabolic Disease
Smiles
ClC1=CN=C(C(F)(C2=NN=C(C3=CN(C(CCCC)=N3)C4=C(C=CC=N4)C(F)(F)F)O2)F)N=C1
Molecular Formula
C20H15ClF5N7O
Molecular Weight
499.82
References & Citations
[1]Narayanan S, et al. Development of Central Nervous System-Penetrant Apelin Receptor Agonists. J Med Chem. 2025 Oct 20.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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